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Article

Empirical validation of pooled whole genome population re-sequencing in Drosophila melanogaster.

PloS one - 1 Jan 2012

Zhu Yuan, Bergland Alan O, González Josefa, Petrov Dmitri A

Abstract excerpt

The sequencing of pooled non-barcoded individuals is an inexpensive and efficient means of assessing genome-wide population allele frequencies, yet its accuracy has not been thoroughly tested. We assessed the accuracy of this approach on whole, complex eukaryotic genomes by resequencing pools of largely isogenic, individually sequenced Drosophila melanogaster strains. We called SNPs in the pooled data and...

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Identifiers

PMID: 22848651
DOI: 10.1371/journal.pone.0041901
PMCID: PMC3406057

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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