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Article

Systemic mastocytosis associated with t(8;21) acute myeloid leukemia in a child: detection of the D816A mutation of KIT.

Pediatric blood & cancer - 15 Dec 2012

Yabe Miharu, Masukawa Atsuko, Kato Shunichi, Yabe Hiromasa, Nakamura Naoya, Matsushita Hiromichi

Abstract excerpt

Systemic mastocytosis (SM) associated with t(8;21) acute myeloid leukemia (AML) is very rare, and the D816 mutation of the KIT gene has previously been detected only in adult patients. We herein report the case of a 5-year-old female presenting with AML harboring t(8;21)(q22;q22). Her AML was refractory to chemotherapy, and bone marrow mastocytosis developed simultaneously at the initial diagnosis and during...

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Share to Child, Preschool
Share to Chromosomes, Human, Pair 21

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Chromosomes, Human, Pair 8

Share to Leukemia, Myeloid, Acute

Share to Mastocytosis, Systemic

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Share to Proto-Oncogene Proteins c-kit

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Source

Identifiers

PMID: 22847983
DOI: 10.1002/pbc.24250

Genes

KIT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Systemic mastocytosis associated with t(8;21) acute myeloid leukemia in a child: detection of the D816A mutation of KIT.PMID 22847983Read ↗

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