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Article

Identification of nucleus pulposus precursor cells and notochordal remnants in the mouse: implications for disk degeneration and chordoma formation.

Developmental dynamics : an official publication of the American Association of Anatomists - 1 Dec 2008

Choi Kyung-Suk, Cohn Martin J, Harfe Brian D

Abstract excerpt

A classically identified "notochordal" cell population in the nucleus pulposus is thought to regulate disk homeostasis. However, the embryonic origin of these cells has been under dispute for >60 years. Here we provide the first direct evidence that all cell types in the adult mouse nucleus pulposus are derived from the embryonic notochord. Additionally, rare isolated embryonic notochord cells remained in the...

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Identifiers

PMID: 19035356
DOI: 10.1002/dvdy.21805
PMCID: PMC2646501

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Identification of nucleus pulposus precursor cells and notochordal remnants in the mouse: implications for disk degeneration and chordoma formation.PMID 19035356Read ↗

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