Article
Genome-wide association study identifies variants associated with progression of liver fibrosis from HCV infection.
Gastroenterology - 1 Nov 2012
Patin Etienne, Kutalik Zoltán, Guergnon Julien, Bibert Stéphanie, Nalpas Bertrand, Jouanguy Emmanuelle, Munteanu Mona, Bousquet Laurence, Argiro Laurent, Halfon Philippe, Boland Anne, Müllhaupt Beat, Semela David, Dufour Jean-François, Heim Markus H, Moradpour Darius, Cerny Andreas, Malinverni Raffaele, Hirsch Hans, Martinetti Gladys, Suppiah Vijayaprakash, Stewart Graeme, Booth David R, George Jacob, Casanova Jean-Laurent, Bréchot Christian, Rice Charles M, Talal Andrew H, Jacobson Ira M, Bourlière Marc, Theodorou Ioannis, Poynard Thierry, Negro Francesco, Pol Stanislas, Bochud Pierre-Yves, Abel Laurent
Abstract excerpt
BACKGROUND & AIMS: Polymorphisms in IL28B were shown to affect clearance of hepatitis C virus (HCV) infection in genome-wide association (GWA) studies. Only a fraction of patients with chronic HCV infection develop liver fibrosis, a process that might also be affected by genetic factors. We performed a 2-stage GWA study of liver fibrosis progression related to HCV infection. METHODS: We studied well-characterized...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.