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Article

Cumulative effect of risk alleles in CFH, ARMS2, and VEGFA on the response to ranibizumab treatment in age-related macular degeneration.

Ophthalmology - 1 Nov 2012

Smailhodzic Dzenita, Muether Philipp S, Chen John, Kwestro Angela, Zhang Alice Yang, Omar Amer, Van de Ven Johannes P H, Keunen Jan E E, Kirchhof Bernd, Hoyng Carel B, Klevering B Jeroen, Koenekoop Robert K, Fauser Sascha, den Hollander Anneke I

Abstract excerpt

PURPOSE: Intravitreal ranibizumab injections currently are the standard treatment for neovascular age-related macular degeneration (AMD). However, a broad range of response rates have been observed, the reasons for which are poorly understood. This pharmacogenetic study evaluated the impact of high-risk alleles in CFH, ARMS2, VEGFA, vascular endothelial growth factor (VEGF) receptor KDR, and genes involved in...

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Source

Identifiers

PMID: 22840423
DOI: 10.1016/j.ophtha.2012.05.040

Genes

ARMS2
CFH
VEGFA
FZD4
KDR
LRP5

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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