Article
Characterization of varicella-zoster virus-encoded ORF0 gene--comparison of parental and vaccine strains.
Virology - 30 Sept 2010
Koshizuka Tetsuo, Ota Megumi, Yamanishi Koichi, Mori Yasuko
Abstract excerpt
The varicella-zoster virus (VZV) Oka vaccine strain (vOka) differs from the parental strain (pOka) at several amino acid positions, but the mutations responsible for the attenuation of vOka have not been clearly defined. The ORF0 of vOka carries some of the mutations. Although we found that the ORF0 of both strains was incorporated into virus particles, the C-terminal region of vOka ORF0 was presented on the...
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