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Article

Hepatitis C virus-induced autophagy is independent of the unfolded protein response.

Journal of virology - 1 Oct 2012

Mohl Bjorn-Patrick, Tedbury Philip R, Griffin Stephen, Harris Mark

Abstract excerpt

Hepatitis C virus (HCV) has been shown to induce autophagy and the unfolded protein response (UPR), but the mechanistic link between the induction of these two cellular processes remains unclear. We demonstrate here that HCV infection induces autophagy, as judged by accumulation of lipidated LC3-II, and that this induction occurs rapidly after infection, preceding the stimulation of the UPR, which occurs only at...

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Identifiers

PMID: 22837205
DOI: 10.1128/JVI.01667-12
PMCID: PMC3457281

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