Disappearance of an activated EGFR mutation after treatment with EGFR tyrosine kinase inhibitors.

doi:10.1016/j.lungcan.2012.07.003

Article

Disappearance of an activated EGFR mutation after treatment with EGFR tyrosine kinase inhibitors.

Lung cancer (Amsterdam, Netherlands) - 1 Oct 2012

Honda Yoshihiro, Takigawa Nagio, Fushimi Soichiro, Ochi Nobuaki, Kubo Toshio, Ozaki Saeko, Tanimoto Mitsune, Kiura Katsuyuki

Abstract excerpt

A 34-year-old Japanese woman presented with left supraclavicular lymph node swelling. Computed tomography scans revealed a mass on the left lower lobe, pulmonary nodules, and pleural effusion. A lymph node biopsy revealed large-cell carcinoma with an epidermal growth factor receptor (EGFR) deletion mutation, L747-T751 in exon 19. Although malignant pleural effusions carried the same EGFR mutation, progressive...

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Disappearance of an activated EGFR mutation after treatment with EGFR tyrosine kinase inhibitors.

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