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Article

The Bcl-2 family member BIM has multiple glaucoma-relevant functions in DBA/2J mice

25 Jul 2012

Abstract excerpt

Axonal insult induces retinal ganglion cell (RGC) death through a BAX-dependent process. The pro-apoptotic Bcl-2 family member BIM is known to induce BAX activation. BIM expression increased in RGCs after axonal injury and its induction was dependent on JUN. Partial and complete Bim deficiency delayed RGC death after mechanical optic nerve injury. However, in a mouse model of glaucoma, DBA/2J mice, Bim deficiency...

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PMID: 22833783
DOI: 10.1038/srep00530

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