Article
Correlation between serotonin uptake in human blood platelets with the 44-bp polymorphism and the 17-bp variable number of tandem repeat of the serotonin transporter.
American journal of medical genetics - 8 Apr 2002
Kaiser Rolf, Müller-Oerlinghausen Bruno, Filler Diana, Tremblay Pierre-Benoit, Berghöfer Anne, Roots Ivar, Brockmöller Jürgen
Abstract excerpt
Dysfunctions of the central serotonin (5-hydroxytryptamine, 5-HT) system seem to be associated with psychiatric disorders such as schizophrenia or depression. Previous studies suggested that a 44-bp insertion/deletion polymorphism of the 5-HT transporter (5-HTT) promoter region might influence the transcriptional activity of the 5-HTT gene, and the insertion variant resulted in increased 5-HTT expression and 5-HT...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.
