Article
Hypermethylation of serotonin transporter gene in bipolar disorder detected by epigenome analysis of discordant monozygotic twins.
Translational psychiatry - 26 Jul 2011
Sugawara H, Iwamoto K, Bundo M, Ueda J, Miyauchi T, Komori A, Kazuno A, Adati N, Kusumi I, Okazaki Y, Ishigooka J, Kojima T, Kato T
Abstract excerpt
Bipolar disorder (BD) is a severe mental disorder characterized by recurrent episodes of mania and depression. Serotonin transporter (HTT) is a target of antidepressants and is one of the strongest candidate molecules of mood disorder, however, genetic study showed equivocal results. Here, we per...
Topics
- Adult
- Bipolar Disorder
- Case-Control Studies
- Cell Line, Transformed
- DNA Methylation
- Diseases in Twins
- Epigenomics
- Female
- Genetic Predisposition to Disease
- Humans
- Lymphocyte Activation
- Male
- Middle Aged
- Serotonin Plasma Membrane Transport Proteins