Mutations and deletions of the SUZ12 polycomb gene in myeloproliferative neoplasms

Abstract excerpt

Alterations of epigenetic marks have an important role in myeloid malignancies. 1 Mutations have been found in several epigenetic regulators including ASXL1, DNMT3A, EZH2, IDH1/2 and TET2. 2 , 3 DNMT3A, IDH1/2 and TET2 are involved in the regulation of DNA methylation. EZH2 belongs to a complex of proteins called ‘polycomb repressor complex 2’ (PRC2). 4 ASXL1 is a regulator of PRC1, the other polycomb complex....

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Acute Myeloid Leukemia Research
• Share to Kruppel-like factors research
• Share to Myeloproliferative Neoplasms: Diagnosis and Treatment