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125I seed irradiation induces up-regulation of the genes associated with apoptosis and cell cycle arrest and inhibits growth of gastric cancer xenografts

24 Jul 2012

Abstract excerpt

BACKGROUND: Iodine 125 (125I) seed irradiation can be used as an important supplementary treatment for unresectable advanced gastric cancer. Here, we aim to comprehensively elucidate the biological effects induced by 125I seed irradiation in human gastric cancer xenograft model by using global expression and DNA methylation analyses. METHODS: The 48 mice bearing NCI-N87 gastric cancer xenografts were randomly...

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PMID: 22827957
DOI: 10.1186/1756-9966-31-61

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