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Radiochemotherapy-induced DNA repair promotes the biogenesis of gastric cancer stem cells

24 Sept 2022

Abstract excerpt

BACKGROUND: Clinically, metastasis and recurrence occurred after routine radiochemotherapy in dozens of cases of gastric cancer, mainly attributed to the role of cancer stem cells (CSCs). Actually, radiochemotherapy could induce DNA damages, leading to activation of DNA repair which might be associated with acquisition of stem cell phenotype. Hitherto, the contribution made by active DNA repair to stemness...

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PMID: 36153608
DOI: 10.1186/s13287-022-03165-8

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