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Patient-Specific Induced Pluripotent Stem Cells for Disease Modeling and Phenotypic Drug Discovery.

Journal of medicinal chemistry - 14 Jan 2016

Tang Shibing, Xie Min, Cao Nan, Ding Sheng

Abstract excerpt

In vitro cell models are invaluable tools for studying diseases and discovering drugs. Human induced pluripotent stem cells, particularly derived from patients, are an advantageous resource for generating ample supplies of cells to create unique platforms that model disease. This manuscript will review recent developments in modeling a variety of diseases (including their cellular phenotypes) with induced...

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CRISPR and Genetic Engineering
Drug Discovery
Induced Pluripotent Stem Cells
Models, Biological
Phenotype

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Pluripotent Stem Cells Research

Precision Medicine

Stem Cell Transplantation

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PMID: 26322868
DOI: 10.1021/acs.jmedchem.5b00789

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