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Article

Does the F508-CFTR mutation induce a proinflammatory response in human airway epithelial cells?

American journal of physiology. Lung cellular and molecular physiology - 15 Sept 2012

Hampton Thomas H, Ballok Alicia E, Bomberger Jennifer M, Rutkowski Melanie R, Barnaby Roxanna, Coutermarsh Bonita, Conejo-Garcia José R, O'Toole George A, Stanton Bruce A

Abstract excerpt

In the clinical setting, mutations in the cystic fibrosis transmembrane conductance regulator (CFTR) gene enhance the inflammatory response in the lung to Pseudomonas aeruginosa (P. aeruginosa) infection. However, studies on human airway epithelial cells in vitro have produced conflicting results...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 22821996
DOI: 10.1152/ajplung.00226.2011
PMCID: PMC3468482

Genes

CFTR
CXCL1
CXCL2
TNF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-22821996-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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