Article
Phenotypic expression of surface antigens of rabbit aortic smooth muscle cells in culture. Monoclonal antibody, 2P1A2, characteristic of smooth muscle cells present in atherosclerotic plaque, is not correlated with cell proliferation.
Atherosclerosis - 1 Nov 1990
Desmoulière A, Lamazière J M, Larrue J
Abstract excerpt
The expression of smooth muscle cell (SMC) antigens was studied in culture by immunofluorescence and immunoelectron microscopy. As specific SMC markers, we used 2 monoclonal antibodies (MAb), 1PC1 and 2P1A2 which are able to detect atherosclerotic plaques in the rabbit. MAb 1PC1 recognizes an antigen expressed on the cell surface, starting on the 7th day in primary culture after serum activation, and then...
Topics
- Animals
- Antibodies, Monoclonal
- Antigens, Surface
- Aorta, Thoracic
- Arteriosclerosis
- Cell Cycle
- Cell Division
- Cell Separation
- Cells, Cultured
- Fluorescent Antibody Technique