Article
ICAM-1 expression by vascular smooth muscle cells is phenotype-dependent.
Atherosclerosis - 1 Mar 2000
Rolfe B E, Muddiman J D, Smith N J, Campbell G R, Campbell J H
Abstract excerpt
Atherosclerosis is an inflammatory disease characterised by increased expression of adhesion molecules for leukocytes on both the surface of dysfunctional endothelium and on smooth muscle cells (SMC) within the lesion. It is also characterised by altered SMC phenotypic expression, indicated by a decreased volume fraction of myofilaments (V(v)myo) [1,2] and changes in gene expression [3]. The present study used an...
Topics
- Analysis of Variance
- Animals
- Aorta, Thoracic
- Cells, Cultured
- Female
- Flow Cytometry
- Gene Expression
- Intercellular Adhesion Molecule-1
- Microscopy, Fluorescence
- Muscle, Smooth, Vascular
- Phenotype