Article
Copy number variation and transposable elements feature in recent, ongoing adaptation at the Cyp6g1 locus.
PLoS genetics - 24 Jun 2010
Schmidt Joshua M, Good Robert T, Appleton Belinda, Sherrard Jayne, Raymant Greta C, Bogwitz Michael R, Martin Jon, Daborn Phillip J, Goddard Mike E, Batterham Philip, Robin Charles
Abstract excerpt
The increased transcription of the Cyp6g1 gene of Drosophila melanogaster, and consequent resistance to insecticides such as DDT, is a widely cited example of adaptation mediated by cis-regulatory change. A fragment of an Accord transposable element inserted upstream of the Cyp6g1 gene is causally associated with resistance and has spread to high frequencies in populations around the world since the 1940s. Here...
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