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Explaining differences in the lifespan and replicative capacity of cells: a general model and comparative analysis of vertebrates

18 Jul 2012

Abstract excerpt

A better understanding of the factors that govern individual cell lifespan and the replicative capacity of cells (i.e. Hayflick's limit) is important for addressing disease progression and ageing. Estimates of cell lifespan in vivo and the replicative capacity of cell lines in culture vary substantially both within and across species, but the underlying reasons for this variability remain unclear. Here, we...

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PMID: 22810428
DOI: 10.1098/rspb.2012.1129

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