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Somatic growth and telomere dynamics in vertebrates: relationships, mechanisms and consequences

15 Jan 2018

Abstract excerpt

Much telomere loss takes place during the period of most rapid growth when cell proliferation and potentially energy expenditure are high. Fast growth is linked to reduced longevity. Therefore, the effects of somatic cell proliferation on telomere loss and cell senescence might play a significant role in driving the growth-lifespan trade-off. While different species will have evolved a growth strategy that...

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PMID: 29335370
DOI: 10.1098/rstb.2016.0446

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