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Article

DNA methyltransferase 3b (DNMT3b), tumor tissue DNA methylation, Gleason score, and prostate cancer mortality: investigating causal relationships.

Cancer causes & control : CCC - 1 Sept 2012

Gillio-Tos Anna, Fiano Valentina, Zugna Daniela, Vizzini Loredana, Pearce Neil, Delsedime Luisa, Merletti Franco, Richiardi Lorenzo

Abstract excerpt

PURPOSE: Aberrant DNA methylation plays a role in prostate cancer progression. We studied the relationships among DNA methyltransferase (DNMT) genotype, DNA methylation, Gleason score, and mortality in two cohorts of prostate cancer patients, previously reported with associations between DNA methylation in GSTP1, APC, and RUNX3 and prostate cancer mortality. Herein, we considered possible causal relationships...

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Identifiers

PMID: 22810147
DOI: 10.1007/s10552-012-0032-9

Genes

APC
GSTP1
RUNX3

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