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Article

HLA-A*02:07 is a protective allele for EBV negative and a susceptibility allele for EBV positive classical Hodgkin lymphoma in China.

PloS one - 1 Jan 2012

Huang Xin, Hepkema Bouke, Nolte Ilja, Kushekhar Kushi, Jongsma Theo, Veenstra Rianne, Poppema Sibrand, Gao Zifen, Visser Lydia, Diepstra Arjan, van den Berg Anke

Abstract excerpt

HLA-A2 protects from EBV+ classical Hodgkin lymphoma (cHL) in Western Europe, but it is unknown whether this protective effect also exists in the Chinese population. We investigated the association of HLA-A2 and specific common and well documented HLA-A2 subtypes with EBV stratified cHL patients (n = 161) from the northern part of China. Quantitative-PCR and sequence-based subtyping was performed to identify...

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Identifiers

PMID: 22355400
DOI: 10.1371/journal.pone.0031865
PMCID: PMC3280205

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