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Article

The substitutions G245C and G245D in the Zn(2+)-binding pocket of the p53 protein result in differences of conformational flexibility of the DNA-binding domain.

Journal of biomolecular structure & dynamics - 1 Jan 2013

Pintus S S, Ivanisenko N V, Demenkov P S, Ivanisenko T V, Ramachandran S, Kolchanov N A, Ivanisenko V A

Abstract excerpt

Transcription activation of the proapoptotic target genes is a means by which the p53 protein implements its function of tumor suppression. Zn(2+) is a known regulator of p53 binding to the target genes. We have previously obtained an evidence that amino acid substitutions in the p53 Zn(2+)-bindi...

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Identifiers

PMID: 22803791
DOI: 10.1080/07391102.2012.691364

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-22803791-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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The substitutions G245C and G245D in the Zn(2+)-binding pocket of the p53 protein result in differences of conformational flexibility of the DNA-binding domain.PMID 22803791Read ↗

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