Article
Mutation studies in the active site of β-glycosidase from Pyrococcus furiosus DSM 3638.
Protein and peptide letters - 1 Jan 2013
Park Sunghoon, Alli Inteaz, Park Kwanhwa, Oh Byungchul, Lee Byonghoon
Abstract excerpt
Sequence alignments and homology modeling of Pyrococcus furiosus thermostable glycosidase (PFTG) showed that the residue 150 is conserved as tryptophan in β-glycosidase and in other related enzymes such as β- mannosidase and β-galactosidase. To elucidate the relationship between the substrate size and geometric shape of the catalytic site of thermophilic β-glycosidase and category of PFTG, the Q77, Q150 and D206...
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