Article
Zinc transporter 8 autoantibodies and their association with SLC30A8 and HLA-DQ genes differ between immigrant and Swedish patients with newly diagnosed type 1 diabetes in the Better Diabetes Diagnosis study.
Diabetes - 1 Oct 2012
Delli Ahmed J, Vaziri-Sani Fariba, Lindblad Bengt, Elding-Larsson Helena, Carlsson Annelie, Forsander Gun, Ivarsson Sten A, Ludvigsson Johnny, Kockum Ingrid, Marcus Claude, Samuelsson Ulf, Örtqvist Eva, Groop Leif, Bondinas George P, Papadopoulos George K, Lernmark Åke
Abstract excerpt
We examined whether zinc transporter 8 autoantibodies (ZnT8A; arginine ZnT8-RA, tryptophan ZnT8-WA, and glutamine ZnT8-QA variants) differed between immigrant and Swedish patients due to different polymorphisms of SLC30A8, HLA-DQ, or both. Newly diagnosed autoimmune (≥1 islet autoantibody) type 1 diabetic patients (n = 2,964, <18 years, 55% male) were ascertained in the Better Diabetes Diagnosis study. Two...
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