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Induction of Fetal HemoglobinIn VivoMediated by a Syntheticγ-Globin Zinc Finger Activator

1 Jan 2012

Abstract excerpt

Sickle cell disease (SCD) and β-thalassemia patients are phenotypically normal if they carry compensatory hereditary persistence of fetal hemoglobin (HPFH) mutations that result in increased levels of fetal hemoglobin (HbF, γ-globin chains) in adulthood. Thus, research has focused on manipulating the reactivation of γ-globin gene expression during adult definitive erythropoiesis as the most promising therapy to...

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Share to Epigenetics and DNA Methylation
Share to Hemoglobinopathies and Related Disorders
Share to Prenatal Screening and Diagnostics

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PMID: 22778925
DOI: 10.1155/2012/507894

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Induction of Fetal HemoglobinIn VivoMediated by a Syntheticγ-Globin Zinc Finger ActivatorPMID 22778925Read ↗

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