Pharmacologic induction of <scp>PGC</scp>‐1α stimulates fetal haemoglobin gene expression

Abstract excerpt

Summary Sickle cell disease (SCD) is a genetic disorder that affects millions around the world. Enhancement of fetal γ‐globin levels and fetal haemoglobin (HbF) production in SCD patients leads to diminished severity of many clinical features of the disease. We recently identified the transcriptional co‐activator PGC‐1α as a new protein involved in the regulation of the globin genes. Here, we report that...

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