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Article

Decreased Cannabinoid CB1 Receptors in Male Tobacco Smokers Examined With Positron Emission Tomography.

Biological psychiatry - 15 Nov 2018

Hirvonen Jussi, Zanotti-Fregonara Paolo, Gorelick David A, Lyoo Chul Hyoung, Rallis-Frutos Denise, Morse Cheryl, Zoghbi Sami S, Pike Victor W, Volkow Nora D, Huestis Marilyn A, Innis Robert B

Abstract excerpt

BACKGROUND: Previous studies showed reduction of brain cannabinoid CB1 receptors in adults with cannabis and alcohol use disorders. Preclinical data suggest that these receptors also contribute to nicotine reward and dependence. Tobacco smoking may confound clinical studies of psychiatric disorders because many patients with such disorders smoke tobacco. Whether human subjects who smoke tobacco but are otherwise...

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Identifiers

PMID: 30121138
DOI: 10.1016/j.biopsych.2018.07.009
PMCID: PMC6388688

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