Article
T-lymphocyte perturbation following large-scale apheresis and hematopoietic stem cell transplantation in HIV-infected individuals.
Clinical immunology (Orlando, Fla.) - 1 Aug 2012
Savkovic Borislav, Macpherson Janet L, Zaunders John, Kelleher Anthony D, Knop Alison E, Pond Susan, Evans Louise, Symonds Geoff, Murray John M
Abstract excerpt
Analysis and mathematical modeling of T-lymphocyte perturbation following administration of granulocyte colony stimulating factor (G-CSF) and two large-scale aphereses are reported. 74 HIV-1 positive antiretroviral-treated individuals were infused with gene- or sham-transduced CD34+ hematopoietic stem cells (HSC) in a Phase II clinical trial. T cell numbers were examined in four phases: 1) during steady state; 2)...
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