Article
Transfer of autologous gene-modified T cells in HIV-infected patients with advanced immunodeficiency and drug-resistant virus.
Molecular therapy : the journal of the American Society of Gene Therapy - 1 May 2007
van Lunzen Jan, Glaunsinger Tobias, Stahmer Ingrid, von Baehr Volker, Baum Christopher, Schilz Andrea, Kuehlcke Klaus, Naundorf Sonja, Martinius Holger, Hermann Felix, Giroglou Tsanan, Newrzela Sebastian, Müller Ingrid, Brauer Francis, Brandenburg Gunda, Alexandrov Alexander, von Laer Dorothee
Abstract excerpt
Drug toxicity and viral resistance limit the long-term efficacy of antiviral drug treatment for human immunodeficiency virus (HIV) infection. Thus, alternative therapies need to be explored. We tested the infusion of T lymphocytes transduced with a retroviral vector (M87o) that expresses an HIV entry-inhibitory peptide (maC46). Gene-modified autologous T cells were infused into ten HIV-infected patients with...
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