Article
Short-cycle structured intermittent treatment of chronic HIV infection with highly active antiretroviral therapy: effects on virologic, immunologic, and toxicity parameters.
Proceedings of the National Academy of Sciences of the United States of America - 18 Dec 2001
Dybul M, Chun T W, Yoder C, Hidalgo B, Belson M, Hertogs K, Larder B, Dewar R L, Fox C H, Hallahan C W, Justement J S, Migueles S A, Metcalf J A, Davey R T, Daucher M, Pandya P, Baseler M, Ward D J, Fauci A S
Abstract excerpt
Although continuous highly active antiretroviral therapy (HAART) is effective for many HIV-infected patients, it can be toxic and prohibitive in cost. By decreasing the total amount of time patients receive medications, intermittent HAART could reduce toxicity and cost. Therefore, we initiated a pilot study in which 10 HIV-infected individuals receiving effective therapy that resulted in levels of HIV RNA <50...
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