Article
Unique CYP3A4 genetic variant in Brazilian tuberculosis patients with/without HIV.
Molecular medicine reports - 1 Jan 2012
Jeovanio-Silva André L, Monteiro Thaís P, El-Jaick Kênia B, do Brasil Pedro E A A, Rolla Valéria C, de Castro Liane
Abstract excerpt
CYP3A4 is involved in tuberculosis (TB) and human immunodeficiency virus (HIV) drug metabolism. Transcriptional activation by rifampicin involves the CYP3A4 gene 5'-upstream region. Consequently, variation may interfere with transcription and enzymatic activity and even drug response. However, genetic polymorphisms and distribution of CYP3A4 allelic frequencies in individuals from Rio de Janeiro remain unknown....
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