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Article

Single nucleotide polymorphism (SNP)-based loss of heterozygosity (LOH) testing by real time PCR in patients suspect of myeloproliferative disease.

PloS one - 1 Jan 2012

Huijsmans Cornelis J J, Poodt Jeroen, Damen Jan, van der Linden Johannes C, Savelkoul Paul H M, Pruijt Johannes F M, Hilbink Mirrian, Hermans Mirjam H A

Abstract excerpt

During tumor development, loss of heterozygosity (LOH) often occurs. When LOH is preceded by an oncogene activating mutation, the mutant allele may be further potentiated if the wild-type allele is lost or inactivated. In myeloproliferative neoplasms (MPN) somatic acquisition of JAK2V617F may be followed by LOH resulting in loss of the wild type allele. The occurrence of LOH in MPN and other proliferative...

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Source

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Identifiers

PMID: 22768290
DOI: 10.1371/journal.pone.0038362
PMCID: PMC3388082

Genes

JAK2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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