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Article

Identification and characterization of two functionally unknown genes involved in butanol tolerance of Clostridium acetobutylicum.

PloS one - 1 Jan 2012

Jia Kaizhi, Zhang Yanping, Li Yin

Abstract excerpt

Solvents toxicity is a major limiting factor hampering the cost-effective biotechnological production of chemicals. In Clostridium acetobutylicum, a functionally unknown protein (encoded by SMB_G1518) with a hypothetical alcohol interacting domain was identified. Disruption of SMB_G1518 and/or its downstream gene SMB_G1519 resulted in increased butanol tolerance, while overexpression of SMB_G1518-1519 decreased...

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Identifiers

PMID: 22768047
DOI: 10.1371/journal.pone.0038815
PMCID: PMC3387226

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