Switching Clostridium acetobutylicum to an ethanol producer by disruption of the butyrate/butanol fermentative pathway.

doi:10.1016/j.ymben.2011.04.006

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Article

Switching Clostridium acetobutylicum to an ethanol producer by disruption of the butyrate/butanol fermentative pathway.

Metabolic engineering - 1 Sept 2011

Lehmann Dörte, Lütke-Eversloh Tina

Abstract excerpt

Solventogenic clostridia are well-known since almost a century due to their unique capability to biosynthesize the solvents acetone and butanol. Based on recently developed genetic engineering tools, a targeted 3-hydroxybutyryl-CoA dehydrogenase (Hbd)-negative mutant of Clostridium acetobutylicum was generated. Interestingly, the entire butyrate/butanol (C(4)) metabolic pathway of C. acetobutylicum could be...

Topics

3-Hydroxyacyl CoA Dehydrogenases
Alcohol Dehydrogenase
Bacterial Proteins
Butanols
Butyrates
Clostridium acetobutylicum
Culture Media
Enoyl-CoA Hydratase
Ethanol
Fermentation
Gene Knockdown Techniques
Genes, Bacterial
Glucose
Mutation
Xylose

Source

Open in PubMed

Identifiers

PMID: 21549853
DOI: 10.1016/j.ymben.2011.04.006

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