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Article

Metabolic flexibility of a butyrate pathway mutant of Clostridium acetobutylicum.

Metabolic engineering - 1 Mar 2017

Yoo Minyeong, Croux Christian, Meynial-Salles Isabelle, Soucaille Philippe

Abstract excerpt

Clostridium acetobutylicum possesses two homologous buk genes, buk (or buk1) and buk2, which encode butyrate kinases involved in the last step of butyrate formation. To investigate the contribution of buk in detail, an in-frame deletion mutant was constructed. However, in all the Δbuk mutants obtained, partial deletions of the upstream ptb gene were observed, and low phosphotransbutyrylase and butyrate kinase...

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PMID: 28159643
DOI: 10.1016/j.ymben.2017.01.011

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