Article
Tellurite resistance gene trgB confers copper tolerance to Rhodobacter capsulatus.
Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine - 1 Oct 2012
Rademacher Corinna, Hoffmann Marie-Christine, Lackmann Jan-Wilm, Moser Roman, Pfänder Yvonne, Leimkühler Silke, Narberhaus Franz, Masepohl Bernd
Abstract excerpt
To identify copper homeostasis genes in Rhodobacter capsulatus, we performed random transposon Tn5 mutagenesis. Screening of more than 10,000 Tn5 mutants identified tellurite resistance gene trgB as a so far unrecognized major copper tolerance determinant. The trgB gene is flanked by tellurite resistance gene trgA and cysteine synthase gene cysK2. While growth of trgA mutants was only moderately restricted by...
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