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Article

Quantitative analysis of WRN exonuclease activity by isotope dilution mass spectrometry.

Mechanisms of ageing and development - 1 Aug 2012

Mangerich Aswin, Veith Sebastian, Popp Oliver, Fahrer Jörg, Martello Rita, Bohr Vilhelm A, Bürkle Alexander

Abstract excerpt

Werner syndrome is a disorder characterized by a premature aging phenotype. The disease is caused by mutations in the WRN gene which encodes a DNA helicase/exonuclease which is involved in multiple aspects of DNA metabolism. Current methods mostly rely on radiometric techniques to assess WRN exonuclease activity. Here we present an alternative, quantitative approach based on non-radioactive isotope dilution mass...

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Identifiers

PMID: 22766507
DOI: 10.1016/j.mad.2012.06.005
PMCID: PMC4586252

Genes

WRN

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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