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Article

Impacts of microRNA gene polymorphisms on the susceptibility of environmental factors leading to carcinogenesis in oral cancer.

PloS one - 1 Jan 2012

Chu Yin-Hung, Tzeng Shu-Ling, Lin Chiao-Wen, Chien Ming-Hsien, Chen Mu-Kuan, Yang Shun-Fa

Abstract excerpt

BACKGROUND: MicroRNAs (miRNAs) have been regarded as a critical factor in targeting oncogenes or tumor suppressor genes in tumorigenesis. The genetic predisposition of miRNAs-signaling pathways related to the development of oral squamous cell carcinoma (OSCC) remains unresolved. This study examined the associations of polymorphisms with four miRNAs with the susceptibility and clinicopathological characteristics...

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Share to Carcinoma, Squamous Cell
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genetic Predisposition to Disease

Share to MicroRNAs

Share to Mouth Neoplasms

Share to Polymorphism, Genetic

Share to Polymorphism, Restriction Fragment Length

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Source

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Identifiers

PMID: 22761899
DOI: 10.1371/journal.pone.0039777
PMCID: PMC3386241

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