Association of single nucleotide polymorphism miRNA-146a (rs2910164) with increased predisposition to oral squamous cell carcinoma in central India population.

doi:10.3233/CBM-230064

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Association of single nucleotide polymorphism miRNA-146a (rs2910164) with increased predisposition to oral squamous cell carcinoma in central India population.

Cancer biomarkers : section A of Disease markers - 1 Jan 2023

Tiwari Shikha, Pandey Ritu, Kumar Vinay, Das Saikat, Gupta Vikas, Vishwakarma Supriya, Nema Rajeev, Sindhuja Tulasi, Hashmi Sana, Kumar Ashok

Abstract excerpt

BACKGROUND: miRNAs play a crucial role in the genesis of cancer, either as tumor suppressor genes or as oncogenes. Single Nucleotide Polymorphisms (SNPs) in the seed region of microRNAs (miRNAs) can dysregulate their levels in the tissues and thereby affect carcinogenesis. The association of SNP in miR-146a (rs2910164) with the risk of oral squamous cell carcinoma (OSCC) has not been understood. OBJECTIVE: In the...

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PMID: 37545224
DOI: 10.3233/CBM-230064
PMCID: PMC12412856

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