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Article

Attenuation of the retinoblastoma pathway in pancreatic neuroendocrine tumors due to increased cdk4/cdk6.

Clinical cancer research : an official journal of the American Association for Cancer Research - 1 Sept 2012

Tang Laura H, Contractor Tanupriya, Clausen Richard, Klimstra David S, Du Yi-Chieh Nancy, Allen Peter J, Brennan Murray F, Levine Arnold J, Harris Chris R

Abstract excerpt

PURPOSE: In mice, genetic changes that inactivate the retinoblastoma tumor suppressor pathway often result in pancreatic neuroendocrine tumors (Pan-NETs). Conversely, in humans with this disease, mutations in genes of the retinoblastoma pathway have rarely been detected, even in genome-wide seque...

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PMID: 22761470
DOI: 10.1158/1078-0432.CCR-11-3264

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-22761470-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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