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Article

Cyclic Di-GMP phosphodiesterases RmdA and RmdB are involved in regulating colony morphology and development in Streptomyces coelicolor.

Journal of bacteriology - 1 Sept 2012

Hull Travis D, Ryu Min-Hyung, Sullivan Matthew J, Johnson Ryan C, Klena Nikolai T, Geiger Robert M, Gomelsky Mark, Bennett Jennifer A

Abstract excerpt

Cyclic dimeric GMP (c-di-GMP) regulates numerous processes in Gram-negative bacteria, yet little is known about its role in Gram-positive bacteria. Here we characterize two c-di-GMP phosphodiesterases from the filamentous high-GC Gram-positive actinobacterium Streptomyces coelicolor, involved in controlling colony morphology and development. A transposon mutation in one of the two phosphodiesterase genes,...

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Identifiers

PMID: 22753061
DOI: 10.1128/JB.00157-12
PMCID: PMC3415515

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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