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Article

rag genes: novel components of the RamR regulon that trigger morphological differentiation in Streptomyces coelicolor.

Molecular microbiology - 1 Sept 2006

San Paolo Salvatore, Huang Jianqiang, Cohen Stanley N, Thompson Charles J

Abstract excerpt

The filamentous bacterium, Streptomyces coelicolor, undergoes a complex cycle of growth and development in which morphological differentiation coincides with the activation of the orphan response regulator RamR and the biosynthesis of a morphogenic peptide called SapB. SapB is a lantibiotic-like molecule derived from the product of the ramS gene that promotes formation of aerial hyphae by breaking the aqueous...

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PMID: 16925552
DOI: 10.1111/j.1365-2958.2006.05304.x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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