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Biosynthesis of clavam metabolites

4 Sept 2012

Abstract excerpt

Naturally occurring clavam metabolites include the valuable β-lactamase inhibitor, clavulanic acid, as well as stereochemical variants with side-chain modifications, called the 5S clavams. Because of the clinical importance of clavulanic acid, most studies of clavam biosynthesis are based on the industrial producer species Streptomyces clavuligerus. Well-characterized early steps in clavam biosynthesis are...

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PMID: 22948564
DOI: 10.1007/s10295-012-1191-0

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Biosynthesis of clavam metabolitesPMID 22948564Read ↗

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