Article
Receptor kinase profiles identify a rationale for multitarget kinase inhibition in immature T-ALL.
Leukemia - 1 Feb 2013
Lhermitte L, Ben Abdelali R, Villarèse P, Bedjaoui N, Guillemot V, Trinquand A, Libura M, Bedin A S, Petit A, Dombret H, Leverger G, Ifrah N, Hermine O, Macintyre E, Asnafi V
Abstract excerpt
Constitutively activated FLT3 signaling is common in acute myeloid leukemia, and is currently under evaluation for targeted therapy, whereas little data is available in T-cell acute lymphoblastic leukemia (T-ALL). We analyzed 357 T-ALL cases for FLT3 mutations and transcript expression. FLT3 mutations (3% overall) and overexpression (FLT3 high expresser (FLT3(High))) were restricted to immature/TCRγδ T-ALLs. In...
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