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Article

Cannabis-dependence risk relates to synergism between neuroticism and proenkephalin SNPs associated with amygdala gene expression: case-control study.

PloS one - 1 Jan 2012

Jutras-Aswad Didier, Jacobs Michelle M, Yiannoulos Georgia, Roussos Panos, Bitsios Panos, Nomura Yoko, Liu Xun, Hurd Yasmin L

Abstract excerpt

BACKGROUND: Many young people experiment with cannabis, yet only a subgroup progress to dependence suggesting individual differences that could relate to factors such as genetics and behavioral traits. Dopamine receptor D2 (DRD2) and proenkephalin (PENK) genes have been implicated in animal studies with cannabis exposure. Whether polymorphisms of these genes are associated with cannabis dependence and related...

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Source

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Identifiers

PMID: 22745721
DOI: 10.1371/journal.pone.0039243
PMCID: PMC3382183

Genes

PENK
DRD2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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