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Article

Disease-causing mutation in PKR2 receptor reveals a critical role of positive charges in the second intracellular loop for G-protein coupling and receptor trafficking.

The Journal of biological chemistry - 13 May 2011

Peng Zhen, Tang Yong, Luo Hunjin, Jiang Fang, Yang Jiannan, Sun Lin, Li Jia-Da

Abstract excerpt

Prokineticins are a pair of signal factors involved in many physiological processes by binding to two closely related G-protein-coupled receptors, PKR1 and PKR2. Recently, mutations in prokineticin 2 (PK2) and PKR2 are found to be associated with Kallmann syndrome and/or idiopathic hypogonadotropic hypogonadism, disorders characterized by delayed puberty and infertility. However, little is known how PKRs interact...

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Identifiers

PMID: 21454486
DOI: 10.1074/jbc.M111.223784
PMCID: PMC3089504

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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