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Article

The role of TNF-α and PAI-1 gene polymorphisms in familial Mediterranean fever.

Modern rheumatology - 1 Jan 2013

Dundar Munis, Kiraz Aslihan, Balta Burhan, Emirogullari Elif Funda, Zararsiz Gokmen, Yurci Alper, Aslan Duran, Baskol Mevlut

Abstract excerpt

OBJECTIVES: Familial Mediterranean fever (FMF) is one of the most serious inherited inflammatory disorders among Jewish, Armenian, Turkish and Arab populations. The imbalance between pro- and anti-inflammatory cytokines may play a role in its etiology. We have investigated whether tumor necrosis factor-alpha (TNF-α) and plasminogen activator inhibitor 1 (PAI-1) gene polymorphisms are associated with FMF and...

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PMID: 22736074
DOI: 10.1007/s10165-012-0687-9

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TNF

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