Plasminogen activator inhibitor-1 genotype 4G/5G associates with skin involvement in Armenian familial Mediterranean fever patients.

doi:10.1007/s00296-024-05653-x

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Article

Plasminogen activator inhibitor-1 genotype 4G/5G associates with skin involvement in Armenian familial Mediterranean fever patients.

Rheumatology international - 1 Nov 2024

Kriegshäuser Gernot, Hayrapetyan Hasmik, Oberkanins Christian, Sarkisian Tamara

Abstract excerpt

There is little and conflicting data on the role of the plasminogen activator inhibitor-1 (PAI-1, SERPINE1) 4G/5G polymorphism in familial Mediterranean fever (FMF). Therefore this study aimed at evaluating the impact of this polymorphism on the disease course in a cohort of 303 Armenian FMF patients. Genotyping for 12 Mediterranean fever (MEFV) gene mutations and the PAI-1 4G/5G (rs1799762) polymorphism were...

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PMID: 38976029
DOI: 10.1007/s00296-024-05653-x

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